Architectural full-system software simulators such as Virtutech Simics = are powerful and versatile research enablers for both architectural = exploration and advanced OS/compiler development. Their main shortcoming = is limited throughput, especially when simulating multiprocessor = systems. Much recent research has focused on FPGA-based platforms to = simulate/emulate hardware. Development turnaround and real-estate = constraints on FGPAs often limit these platforms from achieving = full-system simulation. In this talk, I will present the ProtoFlex = hybrid emulation/simulation framework for accelerating full-system = multiprocessor simulation using FPGAs. In ProtoFlex, only a small set of = frequently encountered behaviors are implemented in the FPGA for = acceleration while a software-based reference simulator implements the = extensive set of infrequent behaviors. Furthermore, the mapping from = simulated processors to the FPGA is virtualized using time-multiplexed = interleaving so that many processor contexts can be emulated by a single = physical pipeline. I will present applications for hybrid = simulation/emulation and performance results comparing simulation = throughput against pure software simulators.=0D =0D