Talk 7.3: 3:15PM–4:15PM
| Session Name: | Biomedical Applications and Artificial Perception |
| Session Time: | 3:15PM–4:15PM |
| Author Name: | Seema Nagaraj |
| Author Email: | seema.nagaraj@utoronto.ca |
| Talk Title: | A Genetic Operational Amplifier |
| Slides: | 7-3.ppt |
| Abstract: | Operational amplifiers are fundamental components in many different electronic circuits. A genetic analog has the potential to be equally useful in the construction of artificial gene networks with complex functions. A gene network that behaves analogously to an electronic operational amplifier is currently being designed, simulated and constructed in E.coli cells. Similar to the electronic circuit, the genetic operational amplifier consists of a differential stage and a gain stage. The differential stage produces output protein at a level that is proportional to the difference between the concentrations of two input proteins. The gain stage then amplifies this signal by producing another protein at a level that is controlled by the differential stage output. Simulation is used to aid in the selection of suitable genetic components. Currently, the differential stage has been constructed, and tests indicate good performance. Preliminary construction and testing of the gain stage also show promising results. |
| Research Group: | Biomedical |
| Degree Program: | Ph.D. |
| Author Bio: | Seema is a Ph.D. student in the Department of Electrical and Computer Engineering and the Institute of Biomaterials and Biomedical Engineering. Her current research involves the design and construction of novel genetic circuits in bacterial cells. Seema holds a Masters of Applied Science degree from the University of Toronto and a Bachelor of Science in Engineering degree from the University of New Brunswick. |